範駿:暨南大學基礎醫學院生化系教授-中文百科頻道

人物經曆

學習經曆

2008年在中國科學技術大學獲得博士學位

1995.09-2003.07安徽中醫藥大學，本科/碩士

工作經曆

2018.09暨南大學，教授

2012.07-2018.08（美）愛默瑞大學，講師/助理教授

2008.07-2012.06（美）愛默瑞大學，博士後，研究員

主要成就

科研成就

發表論文

1.Xia, S., Lin, R., Jin L, Zhao, L., Kang HB, Pan, Y., Liu, S., Qian, G., Qian,Z., Konstantakou,E., Zhang, B., Dong, J.T., Chung, R., Abdel-Wahab, O., Merghoub, T., Zhou,L., . Kudchadkar, R.R., Lawson, D., Lonial, S., Khoury, H.J., Khuri, F.R., Lee, B.H., Boise, L.H., Arbiser, J., Pollack, B.P., Fan, J. *, Lei, Q.Y. *and Chen, J. * (2016) Prevention of dietary fat-fueled ketogenesis attenuates BRAF V600E-positive melanoma Cell Metabolism (2017) Feb 7;25(2):358-373. doi: 10.1016/j.cmet.2016.12.010. Epub 2017 Jan 12) * 共同通訊作者（IF=20.1）

2.Lin, R.-T., Elf, S., Shan, C., Kang, H.-B., Shan, C., Kang, H.-B., Zhou, L., Hitosugi, T., Zhang, L., Zhang, S., Seo, J.H, Xie, J., Tucker, M., Gu, T.-L., Sudderth, J.A., Jiang,L., DeBerardinis R.J., Wu, S., Li, Y., Mao, H., Chen, Z.G., Hurwitz,S.J., Lonial, S., Arellano, M., Khoury, H.J., Khuri, F.R., Lee, B.H., Lei, Q.-Y., Brat, D.J., Ye, K., Boggon, T.J., He, C., Kang, S. *, Fan, J. *, and Chen, J*. (2015) 6-phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumor growth by inhibiting LKB1-AMPK signalingNature Cell Biology 2015, doi:10.1038/ncb3255 共同通訊作者（IF=22.0）

3.Shan, C., Kang, H.-B., Elf, S., Xie, J., Gu, T.-L., Aguiar Mike, Scott Lonning, Hitosugi, T., Chung T-W, Martha Arellano , Khoury, H.J., Khuri, F.R., Shin, D.M., Boggon, T. and Fan, J. (2014) Tyr-94 Phosphorylation Inhibits Pyruvate Dehydrogenase Phosphatase 1 and Promotes Tumor Growth. J. Biol. Chem. 2014, 289:21413-21422通訊作者（IF=4.125）

4.Shan, C., Elf, S., Ji, Q., Kang, H.-B., Zhou, L., Hitosugi, T., Zhang, L., Seo, J.H., Xie, J., Tucker, M., Gu, T.-L., Sudderth, J.A., DeBerardinis R.J., Wu, S., Li, Y., Mao, H., Chen, P., Lonial, S., Arellano, M., Khoury, H.J., Khuri, F.R., Lee, B.H., Brat, D.J., Ye, K., Boggon, T.J., He, C., Kang, S., Fan, J. *, and Chen, J*. (2014) Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth. Molecular Cell (10.1016/j.molcel.2014.06.020.) *共同通訊作者（IF=14.714）

5.Fan, J.*, Lin, R., Xia, S., Chen, D., Elf, S., Liu, S., Pan, Y., Xu, H., Shan, C., Zhou,L., Lei,Q., Li,Y., Mao, H., Lee, B.H., Gaddh, M., Arellano, M.L., Khoury, H.J., Khuri, F.R., Gaddh, M., Doetsch, P.W., Lonial, S., Boggon, T.J., Curran, W.J. and Chen, J*. (2016) Tetrameric Acetyl-CoA Acetyltransferase 1 Is Important for Tumor growth.Molecular Cell 2016 Dec 1;64(5):859-874. doi: 10.1016/j.molcel.2016.10.014. Epub 2016 Nov 17.) * 第一作者和共同通訊作者（IF=14.714）

Preview: Drugging ACAT1 for Cancer Therapy. Javier Garcia-Bermudez, Kivanç Birsoy (2016) Molecular Cell DOI: http://dx.doi.org/10.1016/j.molcel.2016.11.023

6.Fan, J. *, Shan, C. *, Kang, H.-B. *, Elf, S., Xie, J., Tucker, M., Gu, T.-L., Aguiar, M., Lonning, S., Chen, H., Mohannadi, M., Britton, L.-M. P., Garcia, B.A., Aleckovic, M., Kang, Y., Kaluz, S., Devi, N., Van Meir, E., Hitosugi, T., Seo, J.H., Lonial, S., Gaddh, M., Arellano, M., Khoury, H.J., Khuri, F.R., Boggon, T.J., Kang, S., and Chen, J. (2013) Tyr-phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate pyruvate dehydrogenase complex. Molecular Cell Jan 30 2014 online publication; 10.1016/j.molcel.2013.12.026 *: 第一作者（IF=14.714）

7.Kang, H.-B. *, Fan, J. *, Lin, R.-T.*, Elf, S., Ji, Q., Seo, J.H., Arbiser, J., Cohen, C Brat, D, Miziorko, H.M., Abdel-Wahab, O., Merghoub, T., Fröhling, S., Scholl, C., Tamayo, P., Barbie, D.A., Lonial, S., Khoury, H.J., Khuri, F.R., Lee, B.H., He, C., Kang, S., and Chen, J. (2014) Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling. Molecular Cell doi:10.1016/j.molcel.2015.05.037 共同第一作者（IF=14.714）

Preview: Addicted to AA (Acetoacetate): A Point of Convergence between metabolism and BRAF Signaling 2015 Aug 6;59(3):333-4. doi: 10.1016/j.molcel.2015.07.024. * Co-first author

8.Fan, J. *, Shan, C., Kang, H.-B., Elf, S., Hitosugi, T., Xie, J., Tucker, M., Gu, T.-L., Khoury, H.J., Khuri, F.R., Lee, B.H., Boggon, T.J., and Chen, J. * (2014) Tyr-301 phosphorylation inhibits pyruvate dehydrogenase by blocking substrate binding, and promotes the Warburg effect. J. Biol. Chem. (published online August 7, 2014 doi:10.1074/jbc.M114.593970) *第一作者和共同通訊作者（IF=4.125）

9.Hitosugi, T. *, Fan, J. *, Chung, T.W. *, Lythgoe, K., Wang, X., Xie, J., Ge, Q., Gu, T.-L., Polakiewicz, R.D., Roesel, J.L., Chen, Z., Boggon, T.J., Lonial, S., Fu, H., Khuri, F.R., Kang, S., and Chen, J. (2011) Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism. Molecular Cell 2011 Dec 23;44(6):864-77. *共同第一作者（IF=14.714）

Preview: Flicking the Warburg Switch—Tyrosine Phosphorylation of Pyruvate Dehydrogenase Kinase Regulates Mitochondrial Activity in Cancer Cells.

Schulzesend, A. and Downward, J. (2011) Molecular Cell 2011 Dec 23;44(6):846-48.

科研項目

線粒體丙酮酸脫氫酶複合體在頭頸部腫瘤代謝中作用機制研究（項目負責人）

靶向乙酰輔酶A乙酰轉移酶1（ACAT1)作為白血病治療新策略的研究（項目負責人）

靶向乙酰輔酶A乙酰轉移酶1（ACAT1)治療白血病研究（項目負責人）