范骏:暨南大学基础医学院生化系教授-中文百科频道

人物经历

学习经历

2008年在中国科学技术大学获得博士学位

1995.09-2003.07安徽中医药大学，本科/硕士

工作经历

2018.09暨南大学，教授

2012.07-2018.08（美）爱默瑞大学，讲师/助理教授

2008.07-2012.06（美）爱默瑞大学，博士后，研究员

主要成就

科研成就

发表论文

1.Xia, S., Lin, R., Jin L, Zhao, L., Kang HB, Pan, Y., Liu, S., Qian, G., Qian,Z., Konstantakou,E., Zhang, B., Dong, J.T., Chung, R., Abdel-Wahab, O., Merghoub, T., Zhou,L., . Kudchadkar, R.R., Lawson, D., Lonial, S., Khoury, H.J., Khuri, F.R., Lee, B.H., Boise, L.H., Arbiser, J., Pollack, B.P., Fan, J. *, Lei, Q.Y. *and Chen, J. * (2016) Prevention of dietary fat-fueled ketogenesis attenuates BRAF V600E-positive melanoma Cell Metabolism (2017) Feb 7;25(2):358-373. doi: 10.1016/j.cmet.2016.12.010. Epub 2017 Jan 12) * 共同通讯作者（IF=20.1）

2.Lin, R.-T., Elf, S., Shan, C., Kang, H.-B., Shan, C., Kang, H.-B., Zhou, L., Hitosugi, T., Zhang, L., Zhang, S., Seo, J.H, Xie, J., Tucker, M., Gu, T.-L., Sudderth, J.A., Jiang,L., DeBerardinis R.J., Wu, S., Li, Y., Mao, H., Chen, Z.G., Hurwitz,S.J., Lonial, S., Arellano, M., Khoury, H.J., Khuri, F.R., Lee, B.H., Lei, Q.-Y., Brat, D.J., Ye, K., Boggon, T.J., He, C., Kang, S. *, Fan, J. *, and Chen, J*. (2015) 6-phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumor growth by inhibiting LKB1-AMPK signalingNature Cell Biology 2015, doi:10.1038/ncb3255 共同通讯作者（IF=22.0）

3.Shan, C., Kang, H.-B., Elf, S., Xie, J., Gu, T.-L., Aguiar Mike, Scott Lonning, Hitosugi, T., Chung T-W, Martha Arellano , Khoury, H.J., Khuri, F.R., Shin, D.M., Boggon, T. and Fan, J. (2014) Tyr-94 Phosphorylation Inhibits Pyruvate Dehydrogenase Phosphatase 1 and Promotes Tumor Growth. J. Biol. Chem. 2014, 289:21413-21422通讯作者（IF=4.125）

4.Shan, C., Elf, S., Ji, Q., Kang, H.-B., Zhou, L., Hitosugi, T., Zhang, L., Seo, J.H., Xie, J., Tucker, M., Gu, T.-L., Sudderth, J.A., DeBerardinis R.J., Wu, S., Li, Y., Mao, H., Chen, P., Lonial, S., Arellano, M., Khoury, H.J., Khuri, F.R., Lee, B.H., Brat, D.J., Ye, K., Boggon, T.J., He, C., Kang, S., Fan, J. *, and Chen, J*. (2014) Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth. Molecular Cell (10.1016/j.molcel.2014.06.020.) *共同通讯作者（IF=14.714）

5.Fan, J.*, Lin, R., Xia, S., Chen, D., Elf, S., Liu, S., Pan, Y., Xu, H., Shan, C., Zhou,L., Lei,Q., Li,Y., Mao, H., Lee, B.H., Gaddh, M., Arellano, M.L., Khoury, H.J., Khuri, F.R., Gaddh, M., Doetsch, P.W., Lonial, S., Boggon, T.J., Curran, W.J. and Chen, J*. (2016) Tetrameric Acetyl-CoA Acetyltransferase 1 Is Important for Tumor growth.Molecular Cell 2016 Dec 1;64(5):859-874. doi: 10.1016/j.molcel.2016.10.014. Epub 2016 Nov 17.) * 第一作者和共同通讯作者（IF=14.714）

Preview: Drugging ACAT1 for Cancer Therapy. Javier Garcia-Bermudez, Kivanç Birsoy (2016) Molecular Cell DOI: http://dx.doi.org/10.1016/j.molcel.2016.11.023

6.Fan, J. *, Shan, C. *, Kang, H.-B. *, Elf, S., Xie, J., Tucker, M., Gu, T.-L., Aguiar, M., Lonning, S., Chen, H., Mohannadi, M., Britton, L.-M. P., Garcia, B.A., Aleckovic, M., Kang, Y., Kaluz, S., Devi, N., Van Meir, E., Hitosugi, T., Seo, J.H., Lonial, S., Gaddh, M., Arellano, M., Khoury, H.J., Khuri, F.R., Boggon, T.J., Kang, S., and Chen, J. (2013) Tyr-phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate pyruvate dehydrogenase complex. Molecular Cell Jan 30 2014 online publication; 10.1016/j.molcel.2013.12.026 *: 第一作者（IF=14.714）

7.Kang, H.-B. *, Fan, J. *, Lin, R.-T.*, Elf, S., Ji, Q., Seo, J.H., Arbiser, J., Cohen, C Brat, D, Miziorko, H.M., Abdel-Wahab, O., Merghoub, T., Fröhling, S., Scholl, C., Tamayo, P., Barbie, D.A., Lonial, S., Khoury, H.J., Khuri, F.R., Lee, B.H., He, C., Kang, S., and Chen, J. (2014) Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling. Molecular Cell doi:10.1016/j.molcel.2015.05.037 共同第一作者（IF=14.714）

Preview: Addicted to AA (Acetoacetate): A Point of Convergence between metabolism and BRAF Signaling 2015 Aug 6;59(3):333-4. doi: 10.1016/j.molcel.2015.07.024. * Co-first author

8.Fan, J. *, Shan, C., Kang, H.-B., Elf, S., Hitosugi, T., Xie, J., Tucker, M., Gu, T.-L., Khoury, H.J., Khuri, F.R., Lee, B.H., Boggon, T.J., and Chen, J. * (2014) Tyr-301 phosphorylation inhibits pyruvate dehydrogenase by blocking substrate binding, and promotes the Warburg effect. J. Biol. Chem. (published online August 7, 2014 doi:10.1074/jbc.M114.593970) *第一作者和共同通讯作者（IF=4.125）

9.Hitosugi, T. *, Fan, J. *, Chung, T.W. *, Lythgoe, K., Wang, X., Xie, J., Ge, Q., Gu, T.-L., Polakiewicz, R.D., Roesel, J.L., Chen, Z., Boggon, T.J., Lonial, S., Fu, H., Khuri, F.R., Kang, S., and Chen, J. (2011) Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism. Molecular Cell 2011 Dec 23;44(6):864-77. *共同第一作者（IF=14.714）

Preview: Flicking the Warburg Switch—Tyrosine Phosphorylation of Pyruvate Dehydrogenase Kinase Regulates Mitochondrial Activity in Cancer Cells.

Schulzesend, A. and Downward, J. (2011) Molecular Cell 2011 Dec 23;44(6):846-48.

科研项目

线粒体丙酮酸脱氢酶复合体在头颈部肿瘤代谢中作用机制研究（项目负责人）

靶向乙酰辅酶A乙酰转移酶1（ACAT1)作为白血病治疗新策略的研究（项目负责人）

靶向乙酰辅酶A乙酰转移酶1（ACAT1)治疗白血病研究（项目负责人）